stevia side effects mayo clinic

Cholesterol: Top foods to improve your numbers. Artificial sweeteners produce the counterintuitive effect of inducing metabolic derangements. Stamataki NS, Crooks B, Ahmed A, McLaughlin JT. It's also associated with several impressive. Taware, A. S., Mukadam, D. S., and Chavan, A. M. Antimicrobial Activity of Different Extracts of Callus and Tissue Cultured Plantlets of Stevia Rebaudiana (Bertoni). Nonnutritive sweeteners and cardiometabolic health: A systematic review and meta-analysis of randomized controlled trials and prospective cohort studies. Mkinen KK. A study published in May 2016 in Molecular and Cellular Endocrinology found that the metabolite steviol boosted progesterone production, as well as caused a response in CatSper, a progesterone receptor of sperm. Theres a big difference between the stevia you buy at the grocery store and the stevia you may grow at home. High-intensity sweeteners. DOI: Azad MB, et al. The amount of sugar alcohol that causes these symptoms varies from person to person. View abstract. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in Type 1 and Type 2 diabetics. Developmental toxicity of steviol, a metabolite of stevioside, in the hamster. Is Stevia Safe? 6 Side Effects That Give You The Answer - STYLECRAZE Read more: 10 Foods You Don't Realize Are Packed With Sugar. Stevia is available in a few different forms. View abstract. Carbohydr.Res 6-1-2011;346(8):1057-1060. According to the Mayo Clinic, signs of allergic reaction may include: Tingling or itching in the mouth. Some have no calories. Thank you, {{form.email}}, for signing up. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. Melis MS. A crude extract of Stevia rebaudiana increases the renal plasma flow of normal and hypertensive rats. Though research on this issue is limited, it's possible that stevia may have an effect on the endocrine system, which includes glands that produce hormones. https://www.cancer.gov/about-cancer/causes-prevention/risk/diet/artificial-sweeteners-fact-sheet. information highlighted below and resubmit the form. A 2017 review exploring health-outcomes and complications linked to zero-calorie sweeteners concluded that not enough studies had been done to make a judgment about stevias overall safety. U.S. Department of Agriculture. Effect of stevia aqueous extract on the antidiabetic activity of saxagliptin in diabetic rats. Stevia Side Effects: Nervous System & Psychological heartburn. Both of these sweeteners are options for people who need to cut table sugar. information is beneficial, we may combine your email and website usage information with Can ice cream really be healthy? Some people have allergic reactions to steviol glycosides that . Poor digestion of sugar alcohol may cause abdominal pain, gas, bloating and diarrhea. Not all research shows that stevia is beneficial to health, however. Artificial sweeteners and other sugar substitutes - Mayo Clinic View abstract. CFSAN/Office of Food Additive Safety. GRN No. U.S. Food and Drug Administration. Abdel-Aal RA, Abdel-Rahman MS, Al Bayoumi S, Ali LA. There's concern that raw stevia herb may harm your kidneys, reproductive system, and cardiovascular system. Effect of Stevia rebaudiana on glucose tolerance in normal adult humans. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Koyama, E., Kitazawa, K., Ohori, Y., Izawa, O., Kakegawa, K., Fujino, A., and Ui, M. In vitro metabolism of the glycosidic sweeteners, stevia mixture and enzymatically modified stevia in human intestinal microflora. Potential complications with the overuse of stevia products during pregnancy include: Researchers still do not understand the full range of risks associated with stevia. Accessed Nov. 14, 2022. A 2013 study supported these findings. It can be hard to know what foods are healthy, with so many options available today, but following a balanced diet and enjoying sugar and other sweeteners in moderation is the best way to keep your body healthy while still enjoying the foods you love. Stevia can cause gastrointestinal side effects in some people, including gas, nausea, and bloating. Stevia Side Effects, Safety, and Health Risks - Greatist We avoid using tertiary references. Can poor sleep impact your weight loss goals? Remain wary and read labels to make sure you're not consuming stevia leaf or crude extracts, which have not been approved by the FDA. AlDeeb OA, Mahgoub H, Foda NH. Yasukawa, K., Kitanaka, S., and Seo, S. Inhibitory effect of stevioside on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Influence of stevioside on hepatic glycogen levels in fasted rats. Still, ingredients that fall under the natural flavor umbrella may be highly processed. Advertising revenue supports our not-for-profit mission. Ajami M, Seyfi M, Abdollah Pouri Hosseini F, et al. However, like all herbs, they have powerful side-effects. Since stevia is a plant-based extract, there's some possibility it can cause allergies or irritation in certain people. Stevia products made with Reb-A are considered safe, even for people who are pregnant or who have diabetes. Some claim that it's entirely harmless, but new studies suggest that it may have some effects on your metabolism. (n.d.). Certain chemicals in stevia are commonly used as natural food sweeteners. That equates to about 12 mg of high-purity stevia extracts per kilogram of body weight per day. View abstract. Effects of stevia, aspartame, and sucrose on food intake, satiety, and postprandial glucose and insulin levels. Artificial sweeteners: Any effect on blood sugar? - Mayo Clinic US Food and Drug Administration. The Side Effects of Truvia | Healthfully The most notable of these ingredients is saccharin. A January 2015 study published in Food and Chemical Toxicology explained that there's little evidence to support that there is any link between allergic reactions and highly purified stevia extracts. Yang, P. S., Lee, J. J., Tsao, C. W., Wu, H. T., and Cheng, J. T. Stimulatory effect of stevioside on peripheral mu opioid receptors in animals. Description and Brand Names - Mayo Clinic - Mayo Clinic View abstract. Ray J, Kumar S, Laor D, et al. View abstract. Low-calorie sweeteners are often perceived as a healthful alternative to sugar, but a new study finds that they may actually increase fat formation. If you have a bowel disease. Can diet help improve depression symptoms? Metabolism 2004;53(10):1378-1381. Though they're rare, stevia's side effects can include gastrointestinal symptoms, decreased blood pressure and blood sugar, and potential impacts on the liver. 2019; doi:10.1542/peds.2019-2765. If youre sensitive to sugar alcohols, choose a brand that doesnt contain erythritol. Stevia sweeteners are broken down by bacteria in the large intestine, but gastrointestinal symptoms like bloating and diarrhea haven't been reported in studies. Grembecka, M. (2015). Int J Obes (Lond). How Does Stevia Compare to Other Zero-Calorie Sweeteners? Stamataki NS, Scott C, Elliott R, McKie S, Bosscher D, McLaughlin JT. Gardana, C., Simonetti, P., Canzi, E., Zanchi, R., and Pietta, P. Metabolism of stevioside and rebaudioside A from Stevia rebaudiana extracts by human microflora. And it may also interact with drugs like lithium. Lemus-Mondaca R, Vega-Galvez A, Zura-Bravo L, Ah-Hen K. Stevia rebaudiana Bertoni, source of a high-potency natural sweetener: A comprehensive review on the biochemical, nutritional and functional aspects. D'Agostino, M., De Simone, F., Pizza, C., and Aquino, R. [Sterols in Stevia rebaudiana Bertoni]. Principles and methods for the risk assessment of chemicals. Proc Natl Acad Sci USA 1985;82:2478-82. Phytochemistry 2003;64:913-21. A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Eating whole is way of eating that focuses on fresh, natural foods. If you are concerned about the potential side effects of stevia, research shows that it is safe to consume and unlikely to cause side effects in most people. Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. Scientific Reports. Check with your physician for additional information about side effects. 2018;122:132-142. Hsieh MH, Chan P, Sue YM, et al. Though research on the long-term effects of stevia is limited, there is no evidence that it causes cancer. What Are the Negative Effects of Stevia? - MedicineNet From wellcurve.in. privacy practices. Int J Occup Environ Health. Heuberger R. Overview of non-nutritive sweeteners. So, practice caution. Rebecca Valdez is a registered dietitian nutritionist and nutrition communications consultant, passionate about food justice, equity, and sustainability. The study found stevia lowered total cholesterol, LDL (bad) cholesterol, and triglycerides with no negative side effects. Consuming too much of any artificial sweetener may cause diarrhea, bloating, gas, or have a laxative. A single copy of these materials may be reprinted for noncommercial personal use only. So try to cut back if you use them a few times a day. View abstract. Stevia Side Effects Mayo Clinic - Explore Recent If you are a Mayo Clinic patient, this could Nat.Prod Commun 2011;6(2):175-178. Brusick DJ. It has many health benefits, and may help protect against several chronic conditions. The Best Sugar Substitutes for People with Diabetes. DOI: Zeratsky K. (2018). The Food and Drug Administration (FDA) considers stevia leaf extract safe for consumption, and it is unlikely to cause side effects in most people. Stevia: Side Effects, Benefits, and More - Healthline Wasuntarawat C, Temcharoen P, Toskulkao C, et al. Metabolism 2004;53:73-6. This information may not fit your specific health circumstances. The amount of sugar alcohol that causes these symptoms varies from person to person. View abstract. 10-22-2003;51(22):6618-6622. Can whole-grain foods lower blood pressure? Again, to be safe, only use the type of stevia that is considered safe by the FDA (anything that's pure stevia extract rather than crude extracts or the leaf itself). Last medically reviewed on December 3, 2018. Stevia is a natural sweetener that comes from a plant. Monk Fruit vs. Stevia: Pros and Cons - Healthline In addition to its use as a natural sweetener, honey is used as an . Jeppesen PB, Gregersen S, Poulsen CR, Hermansen K. Stevioside acts directly on pancreatic beta cells to secrete insulin: actions independent of cyclic adenosine monophosphate and adenosine triphosphate-sensitive K+-channel activity. Video of the Day The Science Behind Stevia Stevia, not to be confused with Splenda, is a sugar substitute sweetener that comes from the plant Stevia rebaudiana, which is native to South America. View abstract. While most people will not experience any side effects from consuming it, stevia blends containing sugar alcohols may cause gastrointestinal symptoms in people with sugar alcohol sensitivity. Barriocanal LA, Palacios M, Benitez G, et al. A review on the improvement of stevia [Stevia rebaudiana (Bertoni). When you eat a sugary treat, your body produces the hormone insulin to help stabilize the sugar in your blood. Int J Clin Res Trials. In general, it is safest to take in small amounts of sugar substitutes. Principles and methods for the risk assessment of chemicals. Stevia is used in sugar- and calorie-reduced food and beverage products as an alternative for variants with sugar. Stevia: Health Benefits and Risks - WebMD Read our. Gregersen S, Jeppesen PB, Holst JJ, Hermansen K. Antihyperglycemic effects of stevioside in type 2 diabetic subjects. And that can make drinking enough water a challenge. It may also drop blood pressure too low or interact with medications that lower blood sugar. Development of rebiana, a natural, non-caloric sweetener. Although hypersensitivity to sugar alcohol is rare, its symptoms can include: Several studies using rodent and human cell cultures have demonstrated the potential gastrointestinal benefits of steviol glycosides. mood swings Read more The 5 Best (and Worst) Sweeteners You Can Eat - Cleveland Clinic Ginkgo biloba has been widely cultivated across the globe for a variety of uses, most of which are medicinal. Artificial sweeteners: Weight loss friend or foe? Sugar alcohols may also slightly tip the carb count. Farid A, Hesham M, El-Dewak M, Amin A. Can You Get Diabetes From Eating Too Much Sugar? Splenda: Is it safe? - Medical News Today Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice. Sugar alcohols, stevia and luo han guo can cause bloating, gas and diarrhea. Artificial sweeteners and other sugar substitutes. But it's not clear whether sugar substitutes can help people manage their weight over the long term. Stevia side effects: What you need to know - Medical News Today The hemodynamic effects of rebaudioside A in healthy adults with normal and low-normal blood pressure. Sucralose can be especially carcinogenic (cancer-causing) when heated, so stevia may be a healthier option for baking. J Nutr. It's about 100 to 300 times sweeter than table sugar, but it has no carbohydrates, calories, or artificial ingredients.. Some people enjoy it, but its a turn-off for others. Chen, T. H., Chen, S. C., Chan, P., Chu, Y. L., Yang, H. Y., and Cheng, J. T. Mechanism of the hypoglycemic effect of stevioside, a glycoside of Stevia rebaudiana. Some people are at an increased risk of developing side effects from regular stevia use. In fact, evidence is still inconclusive in many ways as to how stevia affects the body over time. This article explains what whole eating is and shares 11 simple ways clean up your. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Some stevia products contain added sugar alcohols that may cause unpleasant symptoms in individuals that are very sensitive to the chemicals. The Mayo Clinic reports that there are a few side effects associated with using stevia: Dizziness Muscle pains Numbness Nausea Gas Bloating These side effects are not serious and only last a short duration if at all. Biol Pharm Bull. A 2019 study reported a possible link between nonnutritive sweeteners, including stevia, and disruption in beneficial intestinal flora. Because of this, it takes only a small amount of artificial sweeteners to sweeten foods. 2017;16(1):55. doi:10.1186/s12937-017-0278-x. 2020;28(10):1290-1300. Andrographis is a medicinal herb used to treat many health conditions, such as the common cold, osteoarthritis, and ulcerative colitis. Both have pros and cons, but is one better for you? Learn about the pros and cons of sugar substitutes, also called artificial sweeteners. https://www.fda.gov/food/food-additives-petitions/high-intensity-sweeteners. In some people, stevia products made with sugar alcohols may cause digestive problems, such as bloating and diarrhea. Stevia - Wikipedia Some stevia side effects include digestive or stomach issues, allergies, an increased risk of weight gain and potential endocrine disruption. Is this how abdominal fat leads to diabetes? View abstract. Study participants consumed 20 milliliters of stevia extract daily for one month. People who may be more likely to experience side effects from stevia include people taking medications to lower blood pressure or blood glucose or those diagnosed with: Stevia leaf extract is safe to consume when pregnant or breastfeeding. View abstract. Bactericidal activity of a fermented hot-water extract from Stevia rebaudiana Bertoni towards enterohemorrhagic Escherichia coli O157:H7 and other food-borne pathogenic bacteria. https://www.fda.gov/consumers/consumer-updates/how-sweet-it-all-about-sugar-substitutes. Chan P, Tomlinson B, Chen YJ, et al. In this case, Reb-A has been evaluated for safety during pregnancy and otherwise. Int J Dent. Factors that may increase the risk of stevia side effects include: There are many different types of steviol glycoside found in stevia, classified into five major groups. information and will only use or disclose that information as set forth in our notice of These problems may be less likely to occur if blood pressure is controlled. This site complies with the HONcode standard for trustworthy health information: verify here. Automatic detention of stevia leaves, extract of stevia leaves, and food containing stevia. 2007;232(1):164-173. Sugar substitutes also are not linked to a higher risk of cancer in people. Select a condition to view a list of vitamins. In general, sugar substitutes are safe for healthy adults. Stevia Safety: Forms, Dosage, and Side Effects - Healthline Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. 2020;150(5):1126-1134. Paul S, et al. Sugar, particularly refined sugars, has been linked to countless health risks, including diabetes and heart disease. Find out here what makes good sugar. Many argue that this means theres nothing natural about them. Berberine is a compound extracted from several plants. So very little is needed to sweeten foods and drinks. Stevia products made with sugar alcohols can also cause bloating, diarrhea and other stomach troubles for some people. Other brands arent made specifically for baking, so youll need to use less. Anything that actively lowers blood pressure can cause health complications with excessive, long-term use. This amounts to about 12 mg per kilograms (kg) of Stevia extract per day. The impact of nonnutritive sweetener on an individuals health may depend on the amount that is consumed, as well as the time of day its consumed. View abstract. According to a 2015 review, there are very few reported cases of stevia allergy. Office of Regulatory Affairs. Sugar substitutes also don't raise the level of sugar in the blood. Is the ketogenic diet right for autoimmune conditions? blood pressure conditions and medications. Additional information about high-intensity sweeteners permitted for use in food in the United States. Ashwell M. Stevia, Nature's Zero-Calorie Sustainable Sweetener: A New Player in the Fight Against Obesity. J Ethnopharmacol 1995;47:129-34. Stevia, not to be confused with Splenda, is a sugar substitute sweetener that comes from the plant Stevia rebaudiana, which is native to South America. In a preliminary 2017 study, rats with diets comprised of up to 3.5 percent stevia for 90 days presented no clinical symptoms and experienced no change in blood chemistry, cellular function, compensation, or appearance. Hives. OTHER NAME(S): Azucacaa, Caa-He-, Ca-A-Jhei, Ca-A-Yupi, Capim Do. Other sugar substitutes called sugar alcohols are not as sweet as sugar. Metabolism 2003;52(3):372-378. J Med Assoc Thai. National Cancer Institute. Since Stevia helps to reduce high blood pressure, it can also low down the blood pressure when consumed on a regular basis. Low-calorie sweeteners increase fat formation, study finds, The benefits and risks of acesulfame potassium. Matsui M, Matsui K, Kawasaki Y, et al. Numbness 2020;10(1). Despite this, stevia contains no calories or carbohydrates, compared to sugar which has 15 calories and 4 grams of carbohydrates per teaspoon. 1997;80 Suppl 1:S121-S128. The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats. This content does not have an Arabic version. FoodData Central. Rios-Leyvraz M, et al. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, Getting Help for a Loved One With Psychosis: It's Complicated, Health News and Information, Delivered to Your Inbox. It is therefore important to buy products certified to contain at least 95 percent steviol glycoside, and that contain no artificial or synthetic sweeteners. Acesulfame potassium is an artificial sweetener. View abstract. When used as a sweetener or to flavor foods, experts do not consider highly purified stevia to cause adverse side effects. WebMD does not provide medical advice, diagnosis or treatment. This could increase how much lithium is in the body and result in serious side effects. Jeppesen, P. B., Gregersen, S., Alstrup, K. K., and Hermansen, K. Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo: studies in the diabetic Goto-Kakizaki (GK) rats. People who drank high levels of diet soda, which typically contains NSSs, had increased rates of metabolic syndrome as well as Type 2 diabetes. Some research on long-term, daily use of artificial sweeteners suggests a link to a higher risk of stroke, heart disease and death overall. You can learn more about how we ensure our content is accurate and current by reading our. Although most of the existing research concerns the two major compounds in stevia stevioside and rebaudioside A (reb A) a 2016 study using human fecal samples concluded that all forms of the compound are probably safe for general use. CFSAN/Office of Food Additive Safety. 2. Reb-A sweeteners are available in liquid, powder, and granulated forms. Stevia: Nature's Zero-Calorie, Sustainable Sweetener. Gastrointestinal Disturbances Associated with the Consumption of Sugar Alcohols with Special Consideration of Xylitol: Scientific Review and Instructions for Dentists and Other Health-Care Professionals. In 1991, the FDA banned stevia over concerns that it was linked tocancer. The use of nonnutritive sweeteners in children. According to the FDA, the acceptable daily intake for steviol equivalents is 4 milligrams (mg) per kilogram of body weight. October 4, 2021. What Other Drugs Interact with Stevia? 2005 - 2023 WebMD LLC. Cardiovascular health: Insomnia linked to greater risk of heart attack. Jeppesen, P. B., Gregersen, S., Rolfsen, S. E., Jepsen, M., Colombo, M., Agger, A., Xiao, J., Kruhoffer, M., Orntoft, T., and Hermansen, K. Antihyperglycemic and blood pressure-reducing effects of stevioside in the diabetic Goto-Kakizaki rat. 2016;22(1):7-17. The same study also suggested nonnutritive sweeteners may induce glucose intolerance and metabolic disorders. View abstract. Accessed Nov. 14, 2022. (2010). While stevia is generally considered safe to be used in food and drink, some extracts of the plant have not been approved by the Food & Drug Administration (FDA). https://www.fda.gov/ora/fiars/ora_import_ia4506.html (Accessed 21 April 2004). Nutr Today. (2015). 5 Best Sugar Substitutes for People with Diabetes, Diet Drinks Won't Protect Heart Health Any Better Than Sugary Drinks: Study, Study: Raw Honey May Improve Blood Sugar and Cholesterol Levels, Stevia, Nature's Zero-Calorie Sustainable Sweetener: A New Player in the Fight Against Obesity, Additional information about high-intensity sweeteners, Effects of aspartame-, monk fruit-, stevia- and sucrose-sweetened beverages on postprandial glucose, insulin and energy intake, Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice, Health outcomes of non-nutritive sweeteners: analysis of the research landscape, Gastrointestinal Disturbances Associated with the Consumption of Sugar Alcohols with Special Consideration of Xylitol: Scientific Review and Instructions for Dentists and Other Health-Care Professionals, Low-Dose Stevia (Rebaudioside A) Consumption Perturbs Gut Microbiota and the Mesolimbic Dopamine Reward System, he hidden hazardous effects of Stevia and sucralose consumption in male and female albino mice in comparison to sucrose, Rebaudioside affords hepatoprotection ameliorating sugar sweetened beverage- induced nonalcoholic steatohepatitis, FDA regulatory approach to steviol glycosides. Stevioside. Stevia may affect the transmission of nerve impulses to and from your central nervous system and may slow down nerve conduction velocity. Many focus on how the gut and brain communicate. Stevia: Generic, Uses, Side Effects, Dosages, Interaction - RxList Journal of Applied Science Research 2010;6(7):883-887. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Learn more about stevia side effects to educate yourself on how to incorporate sweeteners into your diet. Nutrition Journal. Health outcomes of non-nutritive sweeteners: analysis of the research landscape. If youre trying to lose weight, this aspect may be appealing. Planta Med 2001;67(9):796-799. Some people use products called sugar substitutes, also known as artificial sweeteners. Guilt-Free Ice Cream Is Trending, but Is It Actually Healthy? However, erythritol is better tolerated than most sugar alcohols, according to the Calorie Control Council, because it is absorbed and eliminated quickly from the body. View abstract. 8 Ways Food Companies Hide the Sugar Content of Foods, 11 Simple Ways to Focus on Whole Foods Instead of Clean Eating, Berberine A Powerful Supplement With Many Benefits, The Top Health Benefits of Prunes and Prune Juice, What to Know About Andrographis Supplements: Potential Benefits and Uses, Kerry Boyle D.Ac., M.S., L.Ac., Dipl. For example, Truvia is a blend of Reb-A and erythritol, and Stevia in The Raw is a blend of Reb-A and dextrose (packets) or maltodextrin (Bakers Bag). EFSA J 2020;18(4):e06106. Stevia may be used in place of table sugar in your favorite foods and beverages. Psychological Effects MNT is the registered trade mark of Healthline Media. Consumption of stevia may be linked to cancer. DOI: Ukiya M, et al. 2014;60(11):1003-1005. Metabolism 2000;49:208-14. Purified stevia leaf extracts (Truvia, PureVia, others). And there are other possible problems. View abstract. However, some may experience the following when consuming products sweetened with stevia: Early studies of stevia suggested it was linked to cancer, causing the initial FDA ban in 1991. 2003;41(3):359-374. View abstract. View abstract. Sugars, granulated. Artificial sweeteners can be a short-term way to help some people lessen their use of sugar and lose or manage weight. And it's best to use sugar substitutes for a short time, or just every once in a while. Stevia Benefits, Types and Potential Side Effects - Dr. Axe The product is said to be a significant obstruction in the body's metabolism process. The study concluded that stevia may act as an endocrine disruptor, or a chemical that can interfere with hormones. Other research is looking at long-term use of sugar substitutes and the gut. Clopidogrel (Oral Route) Side Effects - Mayo Clinic

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